Assays and Sensors

Few bioprocess variables are easy to monitor. The traditional ones available are pH, temperature, and dissolved oxygen concentration. Others measurements provide such valuable information that elaborate analytical procedures may be justified, e.g., DNA content and specific enzyme concentrations. Ammonium ion concentration is particularly interesting in a process when this ion is the sole source of nitrogen. Monitoring ammonium ion concentration rapidly enough for its control in a bioreactor is difficult. Specific ion electrodes exist for rapid measurement of ammonium but are poorly suited for continuous monitoring. The measurement system has to supply an accurate and precise signal with minimal dead time, rapid response, and extended reliability.

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On-line determination of ammonium ion