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Angel E. García
Department Head
Professor of Physics; Senior Constellation Chaired Professor in Biocomputation and Bioinformatics
Contact:
(518) 276-4206
angel@rpi.edu
http://origami.phys.rpi.edu
Education:
Ph.D., Theoretical Physics, Cornell University.
M.S., Physics, University of Puerto Rico, Rio Piedras
B.S., Physics (Magna cum Laude), University of Puerto Rico, Rio Piedras
Career Highlights:
García received a Ph.D. in Theoretical Physics from
Cornell
University
. He is a fellow of the American Physical Society and a member of the Biophysical Society, The Protein Society, the AAAS, and the American Chemical Society. He received the Edward Bouchard prize of the American Physical Society in 2006.
García is an Associate Editor of Proteins, Structure, Function and Bioinformatics, a member of the editorial board of the Biophysical Journal, Molecular Simulations, and a member of the Faculty of 1000 for BioMed Central.
Research Interests:
Professor Garcia's research interests are theoretical and
computational aspects of the structure, dynamics and stability of
biological molecules.
Selected Publications:
S. Gnanakaran, R. Nussinovand A. E. García, “Atomic level description of amyloid beta dimer formation” J Amer. Chem Soc. (Communications) 128: 2158-2159 (2006)
A.E. Garcia and J. N. Onuchic, “Folding a protein in the computer: Reality or hope?”
(Commentary) STRUCTURE 13: 497-498 (2005)
D. Paschek, S. Gnanakaran, and A.E. García, “Simulations of the Pressure and Temperature Unfolding of an Alpha Helical Peptide,” Proc. Natl. Acad. Sci. (USA) 102: 6765-6770 (2005)
D. Paschek and A.E. García, “Reversible temperature and pressure denaturation of a protein fragment: Replica exchange molecular dynamics simulation study,” Phys. Rev. Let. 93, 238105 (2004)
S. Gnanakaran, Robin M. Hochstrasser and Angel E. García. “Nature of structural inhomogeneities on folding a helix and their influence on spectral measurements,” Proc. Natl. Acad. Sci. 101: 9229-9234 (2004).
A.E. García and J.N. Onuchic, "Folding a protein in a computer; an atomic description of the folding/unfolding of protein A.," Proc. Natl. Acad. Sci. 100: 13898-13903 (2003).
M.S. Cheung and A.E. García and J. N. Onuchic, “Protein folding mediated by solvation: water expelling and formation of the hydrophobic core occur after the structural collapse,'' Proc. Natl. Acad. Sci. (USA) 99: 685-690 (2002)
A.E. García and K.Y. Sanbonmatsu, "Alpha helical stabilization by side chain shielding of backbone hydrogen bonds," Proc. Natl. Acad. Sci. (USA) 99: 2782-2787 (2002)
A.E. Garcia and K.S. Sanbonmatsu, ''Exploring the Energy Landscape of a beta hairpin in explicit solvent," Proteins, Str. Funct. & Genet. 42: 345-354 (2001)
G. Hummmer, S. Garde , A.E. García and L.R. Pratt, “New Perspectives on Hydrophobic Effect, Chem. Phys. 258: 349-370 (2000)
H. Nymeyer, A.E. Garcia and J.N. Onuchic, “Folding Funnels and Frustration in Off-Lattice Minimalist Protein Landscapes," Proc. Natl. Acad. Sci. ( USA ), 95: 5921-5928 (1998)
G. Hummer, S. Garde, A.E. García, M. Paulaitis and L.R. Pratt, “The Pressure Dependence of Hydrophobic Interactions is Consistent with the Observed Pressure Denaturation of Proteins," Proc. Natl. Acad. Sci. 95: 1552—1555 (1998)
G. Hummer, S. Garde, A.E. García, A. Pohorille, and L.R. Pratt, “A Heuristic Molecular Model of Hydrophobic Interactions," Proc. Natl. Acad. Sci. 93: 8951-8955 (1996)
A.E. Garcia, “Large-Amplitude Non-Linear Motions in Proteins," Phys. Rev. Lett. 68: 2696-2700 (1992)
Professional Appointments:
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2005-present
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Senior Constellation Professor for Biocomputation and Bioinformatics, Rensselaer Polytechnic Institute, Troy, NY
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2001-2005
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Group Leader, Theoretical Biology and Biophysics Group Theoretical Division, Los Alamos National Laboratory (LANL), Los Alamos, NM
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1989-2005
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Staff Member, Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory Los Alamos, NM
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